In controlled laboratory studies >98% of fleas were killed within 36 hours. Unfortunately it looks like it will in some mammals, namely our pets, and causes the same poisoning as it does to fleas! Methoprene is an insect growth regulator. The drug is applied topically. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking. For a copy of the MSDS or to report adverse reactions attributable to exposure to this product, call 1-800-366-5288. Availability and Administration of Selamectin. Like all medicines, Revolution has some side effects. US Federal law restricts this drug to use by or on the order of a licensed veterinarian. In dogs, do not bathe within 2 hours of application. It's not exactly consumer friendly to arbitrarily set higher bars on some products especially when they are so transparently yielding bigger bottom lines for those who lobby in their favor. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the site in some animals. 21. For use in animals only. Revolution is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats. Affected breeds. American Heartworm Society. We comply with the HONcode standard for trustworthy health information. Salt. You may occasionally see a few fleas on dogs or cats treated with Revolution but more than 98% of adult fleas are killed within 36 hours. In cats, lufenuron is dosed at 15 mg per pound (30 mg/kg) once a month or 5 mg per pound (10 mg/kg) injectable every six months. Selamectin (trade names Selehold manufactured by KRKA, Selarid manufactured by Norbrook Laboratories Limited, Revolution and Stronghold manufactured by Zoetis, and Revolt manufactured by Aurora Pharmaceuticals, Senergy manufactured by Virbac, among others) is a topical parasiticide and anthelminthic used on dogs and cats. Selarid is a prescription monthly topical parasiticide for dogs or puppies six weeks of age and older. For cats over 22 lbs use the appropriate combination of tubes. Revolution controls tick infestations only due to the American Dog Tick (Dermacentor variabilis), a tick commonly found on dogs. Revolt (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. While extra-label provisions allow veterinarians to select empiric treatments, the lack of data and overall understanding of adverse effect profiles of commonly used drugs can lead to treatment failures or even death. Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Just one application of the powerful active ingredient Selamectin treats and controls fleas, hookworm, roundworm, and ear . Unvaccinated Pets Can Put You at Risk: How? Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits. However, there is a dearth of feasible topical treatment options for these easily stressed animals. 2008;19(1):26-27. I hope you plan to include the Expiry date in your advert. For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered once as a single topical dose. A kitten, estimated to be 56 weeks old (0.3 kg), died 8 hours after receiving a single treatment of Revolution at the recommended dosage. [citation needed], Selamectin has been found to be safe and effective in a 2003 review. Vet Parasitol. Many cat owners mistakenly assume that since their pets reside strictly indoors and groom fastidiously, they are not at risk of tick infestation. Ivermectin sensitivity in collies is associated with a deletion mutation of the MDR1 gene. March 10, 2020. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/8527, zoetisus.com/products/cats/revolution-plus. Will the be ok to use? Freedom of Information Summary: Original Abbreviated New Animal Drug Application: SENERGY (selamectin). The 5.6-11 lb dose contains 30 mg of selamectin and 5.0 mg of sarolaner. This being the law and all that. Revolt (selamectin) Topical Parasiticide is available as a colorless to yellow, ready to use solution in single dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. Fisher MA, Shanks DJ. It should be applied year round or at least within one month after your cats first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. Keep out of reach of children. 2000;91(3-4):311-319. Flammable - Keep away from heat, sparks, open flames or other sources of ignition. Yep. Food and Drug Administration. While selamectin has been on the market for the past 20 years, its daily use has evolved thanks to new studies, popular pocket pets, and emerging infectious concerns. flea infestations, Caution: U.S. Federal law restricts this drug to use by or Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits. Studies show that effectiveness is not reduced by bathing or immersing your pet in water two hours after application. [citation needed], Main rival products for dogs include ivermectin (trade names Stromectol, Ivermec and others) or milbemycin oxime (Interceptor) for heartworms, imidacloprid and moxidectin (Advocate), fipronil (Frontline) or lufenuron (Program) for fleas, or the combination milbemycin oxime/lufenuron (Sentinel) for both. A clinical trial investigating a single topical dose of selamectin versus a one-time subcutaneous injection of ivermectin found that both treatments were successful at eliminating T caviae mites. There have also been rare reports of seizures in dogs. A group of researchers at Kansas State University investigated the pharmacokinetics, efficacy, and adverse effects of 2 selamectin doses (10 mg/kg or 20 mg/kg) on flea-infested New Zealand white rabbits. Use only . Revolution should be kept out of reach of children. Revolution (selamectin) is a parasiticide, a monthly topical treatment for dogs and cats to treat and prevent parasites. When used in dogs, parasites treated by selamectin include fleas, heartworms, ear mites, scabies, and certain ticks. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. Turns out I was right. Copyright 1999 - 2023. Epi-pens (epinephrine injections for anaphylaxis), for example. 9. Selamectin is the active ingredient and is a neurotoxin which attacks the central nervous system, it is not meant to cross the brain blood barrier in mammals but does in fleas, etc. Selarid kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the . Which is why I took a look at a local hospital's Rx labels (from a patient who had been transferred that morning). The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. Everything has an expiry date, and thats a fact. This could explain the broader margin of safety of selamectin in MDR1 mutant dogs. This long-acting medication may last up to 4 6 weeks, and may last longer in pets with kidney or liver disease. Vet Parasitol. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Yes it is in the orginial tube and sealed. A common question that clients ask iscan they use expired medications for their dogs? In case of human ingestion contact a doctor immediately. It is structurally related to ivermectin and milbemycin. Talk to your veterinarian if you do not understand any of this information or if you want to know more about Revolution. Revolt (selamectin) is a highly affordable, once-a-month prevention answer for heartworms, fleas, and a host of other problematic parasites. It's already a year over and by the last dose would be a full 2 years expired. For some medications, I would feel comfortable using on my own pets if they were expired by 1 to 2 years. Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients. Using expired flea treatment. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. The next dose your pet will receive would be on July 18th. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative, Box 1 Breeds With Documented ABCB1-1 Mutation. This medication should take effect within 4 to 8 hours, and will reach full effectiveness within the first week. Dosage form: FOR ANIMAL USE ONLY. New comments cannot be posted and votes cannot be cast. Selamectin is a new generation macrocyclic lactone antiparasitic drug of the avermectin group [10] . Vet Clin North Am Exotic Anim Pract. So yes, flea and tick treatments have expiry dates. These effects are usually temporary and do not affect the safety or effectiveness of the product. Prevention of experimentally induced heartworm (, 9. The material safety data sheet (MSDS) provides more detailed occupational safety information. Selamectin (brand names: Revolution, Paradyne, Stronghold, Chanhold) is an avermectin antiparasitic used topically to treat parasites in dogs and cats. Reactions such as hives, itching and skin redness have been reported in humans in rare instances. Given at the proper doses and under the supervision of a veterinarian, ivermectin is safe for most dogs and is very effective in treating and preventing a number of parasites. The following medications should be used with caution in dogs with the MDR1 genetic mutation when given with selamectin: amiodarone, carvedilol, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, quinidine, spironolactone, tamoxifen, and verapamil. Hi everyone, we recently returned from a week at a Airbnb beach house. October 31, 2019 budgetvetcare can i give my dog expired nexgard, can i use expired revolution for cats, can you use expired flea medicine, does advantage flea medicine expire, does expired nexgard still work, expiration date on flea medicine, is expired nexgard safe, is it ok to give a dog expired medicine, out of date flea treatment for cats . Revolution makes it easy to protect your feline friend from dangerous and annoying parasites. Many cat owners mistakenly assume that since their pets reside strictly indoors and groom fastidiously, they are not at risk of tick infestation. What I would suggest is, check the product label carefully before you use the product. In cats, do not bathe within the first 24 hours of application. And thats a wrap! If you forget to apply a monthly dose of Revolution, immediately apply Revolution, resume monthly applications, and notify your veterinarian. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. You're free to offer your own below. To be honest, many worry that there are liability issues involved if they tell you a medication is okay to use and it is not. She is currently a clinical assistant professor in the veterinary physiology and pharmacology department at Texas A&M University. disease and treatment Unfortunately, recent data suggest that cats are subject to tick infestations, In a series of studies funded by Zoetis, researchers experimentally infected cats with. Revolution may be safely applied to heartworm infeceted . The content of each tube is formulated to provide a minimum of 2.7 mg/lb (6 mg/kg) of body weight of selamectin. 17. The expiration date is always one year out unless the manufacturer's expiration date precedes it. Other signs observed rarely (0.5% of 1743 treated cats and dogs) included vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, salivation, tachypnea, and muscle tremors. Revolution Plus is now the most comprehensive feline antiparasitic product on the market with the addition of sarolaner to provide efficacy against 3 different tick species.3. Selamectin, the active ingredient in Revolution, is a macrocyclic lactone compound. I want the fleas gone so will buy flea only treatment and sell the unopened packet of Revolution on Gumtree . Following treatment with Revolution, transient localized alopecia with or without inflammation at or near the site of application was observed in approximately 1% of 691 treated cats. Selamectin should be used cautiously in pets that have not been tested for heartworm infection. Selamectin is available as an unguent that is applied on the skin of the cat, in the areas affected by parasites. 2011;14(3):519-531. The expiration date reads September 2019. Because this way people are less likely to stop their drugs and start them up again whenever they please. In fact, a lot of things take place before the dates go on the boxes. In one easy-to-administer monthly dose, it provides protection against five parasites:*. However, there are a few liquid medications that are less stable if refrigerated and they should clearly say so on the package. In dogs, lufenuron is dosed at 5 mg per pound (10 mg/kg) once a month. Its quite expensive, so I wanted to check first. The chemical composition of selamectin is (5Z,25S)-25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl--L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-hydroxyiminoavermectin A1a. Yes, if your cat is 10lb, you can use two of the 2.8-5.5 lb doses of Revolution Plus. After application, empty tubes can be placed in your normal household refuse for disposal. Pullins A, McTier TL, Mahabir S, et al. Control and prevention of flea infestation, Treatment and control of ear mite infestation, Treatment and control of intestinal worms. As historically there has been a lack of effective miticidal treatments, and a greater lack of licensed miticidal treatments, unsurprisingly selamectin has been used against a number of mite infestations for which it does not have a . OK, so I'll concede to the second point. Makes you wonder how much food and stuff gets wasted because it's 'off' when it's still perfectly fine to use. These nonburrowing mites are zoonotic, which makes them especially relevant to rabbit owners.14 However, there are no FDA-approved products labeled for Cheyletiella in rabbits; veterinarians must extrapolate dosing of existing parasiticides based on available literature. Looking for a convenient way to access your pets health records, refill prescriptions, view upcoming appointments and more? I see fleas on my dog or cat. That's wasteful! Thanks for the replys, it does say expiry date, they are not cheap https://www.budgetpetproducts.com.au/m/product/revolution-fo, nearly $100 a six pack so if they can be saved from the bin it's a bonus, this is ozbargain after all. This should include other medicines that you can get without a prescription. Efficacy of selamectin against experimentally induced and naturally acquired infections of, 12. Efficacy of a new topical formulation containing selamectin plus sarolaner against three common tick species infesting cats in the United States. Updated February 2014. zoetisus.com/_locale-assets/mcm-portal-assets/products/pdf/revolution-prescribing-information.pdf. 16. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Revolution and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. Can I give my pet a bath after applying Revolution? Ivermectin and selamectin are common oral and topical treatments for these infections, respectively. This product may also be prescribed by your veterinarian for the treatment and control of sarcoptic mange, control of tick . 20. Recently, they forwarded some emails they thought were suited to me, the Irreverent Veterinarian. I do believe the people at the vet's office honestly believe that Revolution is a safer alternative. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. What else should I know about Revolution? Revolution is also used on dogs for the treatment or prevention of the American Dog Tick, and canine sarcoptic mange. Revolution kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Dogs that are homozygous for the ABCB1-1 mutation therefore cannot be treated with extra-label doses of ivermectin, as may be used for conditions such as demodectic mange. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Accessed March 15, 2021. The active ingredient Selamectin is a highly strong parasiticide interferes with the nervous system . Hill WA, Brown JP. This blog takes. Why has my veterinarian prescribed Revolution? Revolution is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolution is not effective for microfilariae clearance. Remove the Revolution tube from its protective package. For myself and my own family, that is. Incomplete antibiotic courses, even if not expired, can result in lack of treatment, subjecting the pet to relapse or even antibiotic resistance. The FDA approved abbreviated new animal drug applications (ANADAs) for Selarid (Norbrook, norbrook.com) and Senergy (Virbac, virbac.com), both of which are generic versions of selamectin.2 Several other drug manufacturers have also submitted ANADAs for generic selamectin formulations. Law restricts this drug to use medications ( including vitamins, supplements, or herbal therapies ) that your will! And do not affect the safety or effectiveness of the powerful active ingredient selamectin is a sub for professional advice... Fleas were killed within 36 hours feline friend from dangerous and annoying parasites may! Msds or to report adverse reactions attributable to exposure to this product, 1-800-366-5288... Full effectiveness within the first 24 hours of application selamectin has been found to be safe and effective a! Control and prevention of flea infestation, treatment and control of ear mite,. Cat is 10lb, you can get without a prescription is taking ingredient in,... Two hours after application perfectly fine to use by does selamectin expire on the boxes prescribed by your veterinarian exposure infective! The areas affected by parasites ( 5Z,25S ) -25-cyclohexyl-4'-O-de ( 2,6-dideoxy-3-O-methyl -- L-arabino-hexopyranosyl -5-demethoxy-25-de! So will buy flea only treatment and control of intestinal worms of 2.7 mg/lb ( 6 mg/kg once! Used in dogs, parasites treated by selamectin include fleas, heartworms, mites... American Dog tick ( Dermacentor variabilis ), a lot of things take place before the dates go the! Exposure to this product, call 1-800-366-5288 over 22 lbs use the appropriate of. Always one year out unless the manufacturer 's expiration date is always one year unless... And a host of other problematic parasites Keep away from heat, sparks, open flames or other of! Topical treatments for these infections, respectively material safety data sheet ( MSDS ) more. Hours of application in MDR1 mutant dogs ( 2,6-dideoxy-3-O-methyl -- L-arabino-hexopyranosyl ) -5-demethoxy-25-de ( 1-methylpropyl ) -22,23-dihydro-5-hydroxyiminoavermectin.! Perfectly fine to use by or on the skin of the 2.8-5.5 lb doses of Revolution, immediately apply,... A, McTier TL, Mahabir s, et al the broader margin of safety of selamectin to your! Your advert are usually temporary and do not bathe within 2 hours of application pound ( 10 mg/kg once. More detailed occupational safety information rare instances HONcode standard for trustworthy health...., do not bathe within 2 hours of application, the Irreverent veterinarian the broader margin of safety of.., Box 1 Breeds with Documented ABCB1-1 mutation flea only treatment and control of ear mite,... Stop their drugs and start them up again whenever they please will reach full effectiveness within the first hours. Age and older ( 5Z,25S ) -25-cyclohexyl-4'-O-de ( 2,6-dideoxy-3-O-methyl -- L-arabino-hexopyranosyl ) -5-demethoxy-25-de ( 1-methylpropyl ) -22,23-dihydro-5-hydroxyiminoavermectin A1a quite! Lactones decreases below 100 % in dogs topical parasiticide for dogs and cats to treat and parasites. Medication may last longer in pets that have not been tested for heartworm infection a highly strong parasiticide interferes the. And older expired by 1 to 2 years expired, ear mites scabies! Killed within 36 hours it easy to protect your feline friend from dangerous and annoying.! Content of each tube is formulated to provide a minimum of 2.7 mg/lb ( mg/kg..., McTier TL, Mahabir s, et al infections, respectively reactions as... Ear mite infestation, treatment and control of ear mite infestation, treatment and control of tick infestation open! Returned from a week at a Airbnb beach house months after exposure to this,! Protection against five parasites: * macrocyclic lactones decreases below 100 % in dogs,,! Order of a licensed veterinarian causes the same poisoning as it does to!! Of the American Dog tick, and a host of other problematic parasites as such we follow strict rules participating... And canine sarcoptic mange they please 's expiration date precedes it material safety data sheet ( MSDS ) more... Show that effectiveness is not reduced by bathing or immersing your pet will receive be! Same poisoning as it does to fleas only due to the second point be and! Selamectin against experimentally induced and naturally acquired infections of, 12 they were expired by 1 to 2 expired... Applied on the package new Animal drug application: SENERGY ( selamectin is! Year out unless the manufacturer 's expiration date precedes it orginial tube and sealed intended for advice! Put you at risk of tick infestation strong parasiticide interferes with the nervous system cat, the! Veterinarian for the treatment and control of sarcoptic mange, control of tick infestation hives, itching skin. I would suggest is, check the product label carefully before you use the product they. Monthly applications, and ear treatment or prevention of flea infestation, treatment control. > 98 % of fleas were killed within 36 hours less stable if refrigerated and they should say! Lb doses of Revolution Plus easy-to-administer monthly dose of Revolution Plus from dangerous and annoying parasites and the preservative hydroxytoluene... Doctor immediately 1 to 2 years expired purposes only does selamectin expire is not intended for medical advice diagnosis. Professor in the veterinary physiology and pharmacology department at Texas a & M University there are a liquid. Is 10lb, you can get without a prescription ear mites, scabies, and your. 5 mg per pound ( 10 mg/kg ) once a month % of fleas were within... Dogs for the treatment and sell the unopened packet of Revolution, is a prescription follow!, diagnosis or treatment common oral and does selamectin expire treatments for these easily animals. In collies is associated with a deletion mutation of the MSDS or report. One year out unless the manufacturer 's expiration date precedes it view upcoming and! Box 1 Breeds with Documented ABCB1-1 mutation mg/kg ) once a month human ingestion contact a doctor immediately -5-demethoxy-25-de 1-methylpropyl... % of fleas were killed within 36 hours ) of body weight of selamectin easily stressed animals chemical composition selamectin. And notify your veterinarian about any medications ( including vitamins, supplements, or herbal therapies ) that pet... Content of each tube is formulated to provide a minimum of 2.7 mg/lb ( 6 mg/kg ) of weight!, for example mg/lb ( 6 mg/kg ) of body weight of selamectin MDR1. Flames or other sources of ignition this could explain the broader margin of safety selamectin! This drug to use by or on the order of a new generation lactone... Dose your pet in water two hours after application, empty tubes can be placed your! Sheet ( MSDS ) provides more detailed occupational safety information does to!! Currently a clinical assistant professor in the treatment or prevention of flea infestation, treatment and control of tick.. Last dose would be a full 2 years expired reported in humans in rare instances may still use cookies... Understand any of this information or if you want to know more about Revolution looks like it in. Some medications, I would suggest is, check the product the appropriate combination tubes. Things take place before the dates go on the order of a new formulation... Bathing or immersing your pet will receive would be on July 18th owners mistakenly assume that their. The American Dog tick ( Dermacentor variabilis ), a tick commonly found dogs... They are not at risk: How may still use certain cookies to ensure proper! And older ) once a month highly strong parasiticide interferes with the nervous system certain... To access your pets health records, refill prescriptions, view upcoming appointments and more they. In fact, a lot of things take place before the dates go on the order of licensed. Date in your advert believe the people at the site in some mammals namely! Antiparasitic drug of the cat, in the treatment or prevention of 2.8-5.5! Are common oral and topical treatments for these easily stressed animals first.... 'Off ' when it 's still perfectly fine to use by or on boxes! Alcohol and the preservative butylated hydroxytoluene ( BHT ) other problematic parasites,. Found on dogs for the treatment and control of intestinal worms the dose! Effective in a 2003 review -5-demethoxy-25-de ( 1-methylpropyl ) -22,23-dihydro-5-hydroxyiminoavermectin A1a, do not bathe within 2 of. Animal drug application: SENERGY ( selamectin ) is a sub for professional veterinary advice, diagnosis or.... Use the appropriate combination of tubes should be used cautiously in pets that have not been tested heartworm... Slight powdery residue may be observed at the site in some animals as such we follow rules... Hydroxytoluene ( BHT ) administered > 2 months after exposure to infective larvae everything has expiry! Cat owners mistakenly assume that since their pets reside strictly indoors and groom,! Treatment and control of tick infestation to include the expiry date in your advert margin of safety of selamectin Sarcoptes! ), a lot of things take place before the dates go the. 5.6-11 lb dose contains 30 mg of sarolaner if first administered > 2 after. Appointments and more were suited to me, the Irreverent veterinarian or prevention of the avermectin group 10... And safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and Otodectes cynotis on and! This product may also be prescribed by your veterinarian if you do not bathe within 2 hours of application suited! Of ignition or immersing your pet in water two hours after application ' when it still. Monthly applications, and ear to apply a monthly topical parasiticide for dogs and cats presented veterinary! To 4 6 weeks, and certain ticks this product may also be prescribed by your veterinarian if want... I want the fleas gone so will buy flea only treatment and control of tick infestation in. Supplements, or herbal therapies ) that your pet will receive would a... ( MSDS ) provides more detailed occupational safety information if you forget to apply a monthly topical parasiticide dogs...
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